• Category: Supplements
  • Brand: MVP Med-Vet Pharmaceuticals
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Calmex-V contains high level acitves along with Valerian Root, to help support healthy nervous system.  


New improved formula!  Now with tryptophan!


(Excludes Sand-Free)

The map below indicates ground transit time via Fed Ex. All orders placed before 3:00 p.m. CST will be shipped the same day.  ALL orders placed Friday (after 3PM)/Saturday/Sunday will be shipped the following Monday.


Orders placed over the weekend (Friday after 3PM/Saturday/Sunday) will be shipped the following Monday.  All vaccines orders are shipped to be received within the same week (ie. Any order placed Wednesday (after 3 p.m. CST), Thursday or Friday to ship 2 day air, we will hold your order to ship on the following Monday).  No vaccines will be shipped on a Friday.

We strongly recommend ALL vaccine orders be shipped 2nd day or Next day air. Vaccines not shipped in this manner are non-returnable/non-refundable.  All vaccine orders are shipped in a bio-cooler with ice ice packs.  

2-DAY AIR:  $22.00
Next Day Air:  $35.00

NOTE  Express order delivery time:  Example:  2 day air (2 business days) - if your order ships on Monday, you will receive it Wednesday.  Air shipping Flat Rates apply to FedEx service only.  Vaccines are not shipped on Fridays - NO Saturday express deliveries unless requested (additional express charges will apply).

WEATHER DELAYS:  We are not able to reimburse air charges due to inclement weather that is not in our control.



Unless item is designated "FOB", or marked "Freight Charges Apply" shipping by ground service is FREE within the contiguous 48 states (Fed Ex ground or SpeeDee only).

 MVP supplements ship FREE (Exlcuding Sand Free).

If shipping to a commercial address: Your package will be delivered during the work week (Monday through Friday).

WHEN ORDERING REMEMBER $35.00 minimum order necessary for shipment.
$35.00 - $75.00 order add $6.95 handling.
ALL products marked FOB (Freight On Board) OR Freight Charges Apply - will incur a freight charge.









National Animal Supplement Council (NASC), an industry group dedicated to protecting and enhancing the health of companion animals and horses throughout the United States. Founded in 2001, NASC Members are industry participants and other stakeholders of the finest animal supplements who are committed to the highest current standards of quality in the industry today.

The Council's overriding goal is to promote the health and well-being of non-human food chain animals that are given nutritional supplements by their owners, and to protect and enhance the integrity of the animal supplements industry.

The cornerstone of NASC's mission is to work cooperatively with state, federal, and international governmental officials to create a legislative and regulatory environment that provides a framework that is Fair, Reasonable, Responsible and Nationally Consistent.

Such an environment of safety, accuracy and quality serves the interests of NASC's members by ensuring that ethical manufacturing and labeling practices are complied with throughout the industry.

NASC Seal of Quality…

As part of its ongoing effort to improve and standardize the animal supplement industry, NASC initiated its Quality Seal Program. The Seal is a way for consumers to know that when they buy a product, they buy from a reputable manufacturer that has successfully completed a facility audit. Different from the NASC logo, the Seal is a privilege for members to use on their products and signifies that the company has been audited for the implementation of specific standards. Members must agree to adhere to NASC’s quality standards, part of which includes submitting to an independent audit to ensure conformance with quality system requirements.



The Vitamin B family is made up of several compounds that support many important roles in the body: protein, fat and carbohydrate metabolism; energy production; proper nerve cell transmission, reproduction, and division (especially rapidly dividing ones such as red blood cells). B vitamins include thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), folic acid (B9), cyanocobalamin (B12), choline, biotin, inositol and others are sometimes referred to as B-vitamins. For most of the B-vitamins, microorganisms in the large intestine make all the horse needs. Only thiamine and riboflavin have NRC dietary requirements. However, research suggests B-vitamin supplementation may be beneficial to horses with little access to fresh pasture and/or during any periods of stress (training, injury, travel, etc.)

Magnesium (Mg) is a macro mineral that is frequently recommended for a wide range of equine health conditions. Magnesium helps to maintain normal muscle and nerve function, a healthy heart, healthy immune system and strong bones. Magnesium aids to regulate blood sugar levels, promotes normal blood pressure, and known to be involved in energy metabolism and protein synthesis. Since a symptom of magnesium deficiency is agitation or anxiety, it is included in many calming supplements.

Valerian Root is an herb with specific actions on the nervous system. It helps maintain a healthy nervous system and balance in horses displaying nervous/anxious behavior. **Valerian root is a banned substance in many organizations, always check competition guidelines regarding its usage.

Thiamine (Vitamin B1) plays a role in supporting carbohydrate metabolism and normal muscle and nerve function. Thiamine supplementation has been shown to have a calming effect in horses displaying anxious/nervous behavior as a result thiamine deficiency and/or increased requirements.

Tryptophan is an amino acid, converted by the body into serotonin, melatonin, and other hormones that transmit nerve signals in the brain. Serotonin is the neurotransmitter in the horse’s brain that helps promote feelings of well-being/contentment as well as balanced behavior.

Taurine is an amino acid found in high concentrations in electrically active tissues such as the brain, heart, retina and muscle. It stabilizes membranes and assists in the movement of electrolytes in and out of cells, which is critical for proper nervous system and muscle health. Taurine is necessary for the absorption of fats and vitamins and helps support normal insulin and glucose levels. It can be found in supplements for growing horses, nervous horses and horses with metabolic issues.

Inositol is closely related to the B-vitamin family and is found in nearly every cell in the body. Because of its location within the cell membrane, it plays two major roles: transporting fats and assisting in nerve transmission. By participating in the action of serotonin, a neurotransmitter whose brain levels are known to be a factor in excess anxiety, inositol may be helpful in promoting a healthy balanced behavior in horses.





SKU:  Size FOB Cost/Serving Price Quantity
73160530 2lb (32 servings) Ships FREE $1.45 $46.45
73160534 5lb (80 servings) Ships FREE $1.34 $107.00
73160538 10lb (160 servings) Ships FREE $1.27 $202.90

Product Ratings and Reviews

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4.8 out of 4.8 stars
  • Mary
  • Crystal Lake, IL
  • Saturday, July 4, 2020
Got this for my mare that is more reactive prior to moving her after being at the same barn for 10 years. I got it to help with the adjustment/transition to being at a new location knowing that this would be an extremely stressful situation. This made the difference for her to be able to transition smoothly to the new location. There has been a noticeable difference in her behavior and reactivity. This has made her transition smooth and easy.
  • Theresa
  • ,
  • Thursday, June 28, 2018
Tried on my gelding and really helped with his anxiety when I trailer him to different places. Also anxious when we trail ride and has really helped with calming him down.
  • Judith
  • East Bethany, NY
  • Friday, March 31, 2017
I have an American Mustang that I adopted four years ago. Spirit has what we would call PTSD from severe torture that he received when he was caught (and I do mean torture... he was used in a certain type of rodeo, and he has both the physical and emotional scars to prove it). Even though I am the only person that he absolutely trusts, Calmex-V has been a God-send! I had used Calmex for years and then switched to the Calmex-V once it became available. This product has helped Spirit go from a horse that had no confidence, was fearful, reactive, and nervous to being a more confident, brave, calm, and tolerant horse. Calmex-V has made it possible for me to train him using positive reinforcement (i.e. his favorite cookies) to the point now that he will walk across big sheets of plastic, aluminum foil, not react when an umbrella is opened right next to him, accept a plastic bag on a training stick to be waved around him, go in the wash stall and be given a bath, allow his hooves to be cleaned in the isle instead of the safety of his stall, and interact with other people without being afraid that he's going to get hurt, especially from a man, and for good reason. Spirit is a walking testament to the effectiveness of Calmex-V. I thank God that I found this product!! MVP, please don't stop making this product!!! Sincerely, Judith and Spirit
  • Kathleen P.
  • Friendsville, PA
  • Tuesday, April 30, 2013
I have a barrel horse that just could not relax,even in the pasture. She has been on Calmex-V for about a month and we can see a big difference in her demeanor.